Ampicillin Natriumsalz

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Ampicillin Natriumsalz
Ampicillin Natriumsalz

Ampicillin is a semi-synthetic derivative of penicillin, active as a broad-spectrum antibiotic.


It is inactivated by beta-lactamases and for this reason a beta-lactamase inhibitor should be considered when using ampicillin. Against gram-positive bacteria, ampicillin has a similar mode of action as benzylpenicillin; against gram-negative bacteria, it has a similar mode of action as chloramphenicol and tetracyclines. In E. coli it inhibits cell wall synthesis.


Used to select for ampicillin resistance in mutated and transformed cells.


A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli. Mode of resistance: cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: gram-negative and gram-positive bacteria.


Soluble in water (50 mg/ml); soluble in 1 M ammonium hydroxide, dilute acids or bases; practically insoluble in alcohol, chloroform, ether and fixed oils.

Formel: C₁₆H₁₈N₃NaO₄S
MW: 371,39 g/mol
Lager Temperatur: Kühlschrank
MDL Number: MFCD00064313
CAS-Nummer: 69-52-3

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Spezifikation Testergebnisse

Synonyms D(-)-α-Aminobenzylpenicillin sodium salt
Storage Store at +4 °C
Loss on Drying 2%
pH 8 - 10 (1% aq soln)
pka pKa = 2,5 (-COOH) pKa = 7,3 (-NH2) at 25 °C
Potency 800 μg/mg

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