Trimethoprim, weißes Pulver
Lieferant: ICN Biomedicals
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Achtung
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Trimethoprim is an antibacterial agent; a specific inhibitor of formylation; a dihydrofolate reductase inhibitor.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
- Presentation: White Powder
- Soluble in a hot 1:1 solution of ethanol:chloroform (50 mg/mL - clear, colorless to faint yellow solution); soluble in chloroform (15 mg/mL - clear, colorless solution), propylene glycol (25 mg/mL), methanol (12 mg/mL); very slightly soluble in water (0.4 mg/mL).
- +4 °C
Formel:
C₁₄H₁₈N₄O₃ MW: 290,32 g/mol Melting Pt: 196…206 °C Lager Temperatur: Kühlschrank |
MDL Number:
MFCD00036761 CAS-Nummer: 738-70-5 |
Spezifikation Testergebnisse
Identity Test | Passes |
FTIR | Conforms to Standard |
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