Trimethoprim, weißes Pulver

Lieferant: ICN Biomedicals
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ICNA0219552701EA 66.8 CHF
ICNA0219552701 ICNA0219552725 ICNA0219552780 ICNA0219552705
Trimethoprim, weißes Pulver
Trimethoprim

Trimethoprim is an antibacterial agent; a specific inhibitor of formylation; a dihydrofolate reductase inhibitor.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.


  • Presentation: White Powder
  • Soluble in a hot 1:1 solution of ethanol:chloroform (50 mg/mL - clear, colorless to faint yellow solution); soluble in chloroform (15 mg/mL - clear, colorless solution), propylene glycol (25 mg/mL), methanol (12 mg/mL); very slightly soluble in water (0.4 mg/mL).
  • +4 °C

Formel: C₁₄H₁₈N₄O₃
MW: 290,32 g/mol
Melting Pt: 196…206 °C
Lager Temperatur: Kühlschrank
MDL Number: MFCD00036761
CAS-Nummer: 738-70-5

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