Dextransulfat Natriumsalz, M.W. ∼ 8,000, weißes Pulver, Reagenzqualität
Lieferant: ICN Biomedicals
Dextran sulphate is a polyanionic derivative of dextran produced by esterification of dextran with chlorosulphonic acid. The sulphur content is approximately 17% which corresponds to an average of 1,9 sulphate groups per glucosyl residue of the dextran molecule. Dextran sulphate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
Dextran sulphate is a polyanionic derivative of dextran produced by esterification of dextran with chlorosulphonic acid. The sulphur content is approximately 17% which corresponds to an average of 1,9 sulphate groups per glucosyl residue of the dextran molecule. Dextran sulphate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used as an anticoagulant, antiviral as well as antilipemic agent.Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein. Exhibits activity as an adjuvant.Antiviral and Antienzyme Activity – Baba et al., have shown in In Vitro studies that DSS inhibits the binding of various enveloped viruses including Human Immunodeficiency Virus (HIV), Herpes Virus (HSV) and Cytomegalovirus (CMV) to cells. Additionally, DSS has also shown to exhibit a potent inhibitory effect on many enzymes, for example hyaluronidase, adenylate cyclase, and amylase. Hofer at al., have shown that DSS induces bacterial translocation in HIV-infected humanized mice.
Soluble in water (100 mg/ml) - clear to slightly hazy yellow solution.
Bitte beachten Research Use Only (RUO).
|
Formel:
(C₆H₇Na₃O₁₄S₃)n |
MDL Number:
MFCD00081551 CAS-Nummer: 9011-18-1 |
Spezifikation Testergebnisse
| Identity Test | Passes |
| pH (1% aq soln) | 5.0 - 7.5 |
| Optical Rotation | +75 ° to 105 ° |
| Loss on Drying |
|
| Residue on Ignition | 35 - 50% |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...