2,6-Di-tert-butyl-p-kresol, kristallines Pulver
Lieferant: ICN Biomedicals
Synonyms:
2,6-Di-tert-butyl-4-methylphenol
, Butylhydroxytoluol
, Ionol
, DBPC
, BHT
Butylated hydroxytoluene is a phenolic antioxidant.
Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
Insoluble in water; freely soluble in toluene, soluble in methanol, ethanol (100 mg/ml), isopropanol, methyl ethyl ketone, acetone, Cellosolve, benzene and most other hydrocarbon solvents. More soluble in food oils and fats than butylated hydroxyanisole.
Bitte beachten Research Use Only (RUO).
|
Formel:
C₁₅H₂₄O MW: 220,35 g/mol Lager Temperatur: Raumtemperatur |
MDL Number:
MFCD00011644 CAS-Nummer: 128-37-0 |
Spezifikation Testergebnisse
| Identity Test | Passes |
| FTIR | Conforms to Standard |
| Melting Point | 68 - 74 °C |
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