Anti-CD8a Mouse Monoclonal Antibody (redFluor™ 710) [clone: RPA-T8]

Lieferant: Tonbo Biosciences
80-0088-T100EA 214 CHF
80-0088-T100 80-0088-T025
Anti-CD8a Mouse Monoclonal Antibody (redFluor™ 710) [clone: RPA-T8]
Antikörper
The RPA-T8 antibody is specific for the 32 to 34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

The RPA-T8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. It is cross-reactive with CD8 in several non-human species, including Baboon, Chimpansee, Cynomolgus and Rhesus. If used together with an alternative anti-human CD8a clone, Hit8a, the RPA-T8 antibody will not block binding of Hit8a to CD8a.

Type: Primary
Antigen: CD8a
Clonality: Monoclonal
Clone: RPA-T8
Conjugation: redFluor™ 710
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Chimpanzee, Baboon, Cynomolgus, Rhesus, Sooty Mangabey
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