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Degassers of all models and formulations are designed to effectively remove dissolved or adsorbed gases from HPLC mobile phases. Removing gases is important in eliminating noise spikes in chromatograms. Bubble formation on the mixing of solvents can lead to a number of problems in HPLC analysis which can be prevented by degassing the mobile phase. Degassers may use the processes of helium purging, vacuum degassing, or sonication to achieve positive results.