Sie suchten nach: Antikörper

Artikel-Nr: (BOSSBS-15968R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15968R-A750

Beschreibung: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localised at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organisation. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7776R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7776R-A555

Beschreibung: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.Tissue specificity:Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.

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Artikel-Nr: (BOSSBS-7774R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7774R-A488

Beschreibung: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1646R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1646R-HRP

Beschreibung: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3955R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3955R-A350

Beschreibung: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7776R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7776R-A350

Beschreibung: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.Tissue specificity:Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7774R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7774R-A750

Beschreibung: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3954R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3954R-A680

Beschreibung: Munc18 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP binding proteins. It is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Munc18 can interact with syntaxins 1, 2, and 3 but not syntaxin 4. It may play a role in determining the specificity of intracellular fusion reactions.Mutations in Munc18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Two Munc18 isoforms have recently been identified. Munc18-1 has been shown to be primarily expressed in brain, while Munc18-2 is expressed in most tissues.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1172R-CY7)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1172R-CY7

Beschreibung: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12028R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-12028R-A350

Beschreibung: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8594R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-8594R-CY3

Beschreibung: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD22 (ankyrin repeat domain 22) is a 191 amino acid protein that contains four ANK repeats. Conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, ANKRD22 is encoded by a gene that maps to human chromosome 10. Chromosome 10 encodes nearly 1,200 genes within 135 million bases, making up approximately 4.5% of the human genome. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8594R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-8594R-CY5

Beschreibung: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD22 (ankyrin repeat domain 22) is a 191 amino acid protein that contains four ANK repeats. Conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, ANKRD22 is encoded by a gene that maps to human chromosome 10. Chromosome 10 encodes nearly 1,200 genes within 135 million bases, making up approximately 4.5% of the human genome. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7907R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7907R-A680

Beschreibung: CDC-like kinase 2 (CLK2) belongs to a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases), which have been shown to phosphorylate serine- and arginine-rich (SR) proteins of the spliceosomal complex, and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the CLK2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3757R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3757R-A350

Beschreibung: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3699R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3699R-CY5

Beschreibung: GPR15 is a probable chemokine receptor,its expression has been reported in CD4(+) T lymphocytes, alveolar macrophages, and the basal surface of the small intestinal epithelium. ESTs have been isolated from normal brain and kidney cancer libraries.This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012].

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3756R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3756R-A750

Beschreibung: PPP1A is a serine/threonine protein phosphatase catalytic subunit that is essential for regulating cellular stress responses in eukaryotes. It binds to magnesium or manganese ions and exists as a monomer. It is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1A is involved in the regulation long term synaptic plasticity and may play an important role in dephosphorylating substrates such as Ca2+/calmodulin dependent protein kinase II.

UOM: 1 * 100 µl

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