Sie suchten nach: Antikörper

Artikel-Nr: (BOSSBS-11114R-CY5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11114R-CY5

Beschreibung: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH8 (protocadherin-8), also known as Arcadlin or PAPC, is a 1,070 amino acid single-pass type I membrane protein that contains six cadherin domains and belongs to the protocadherin family. Localized to the cell membrane and expressed specifically in fetal and adult brain, PCDH8 is thought to play a role in cell adhesion events in the central nervous system (CNS). PCDH8 is inactivated or silenced in breast cancer, suggesting a possible role in tumor suppression. Two isoforms of PCDH8 that differ in their cytoplasmic tails are expressed due to alternative splicing events.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15228R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15228R-A555

Beschreibung: Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf165 gene product has been provisionally designated C6orf165 pending further characterisation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15228R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15228R-CY3

Beschreibung: Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf165 gene product has been provisionally designated C6orf165 pending further characterisation.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1228R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1228R-HRP

Beschreibung: Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1228R-CY5.5)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-1228R-CY5.5

Beschreibung: Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-15472R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-15472R-A555

Beschreibung: HGD is a 445 amino acid protein that belongs to the homogentisate dioxygenase family and is involved in the pathway of amino acid degradation. Expressed at high levels in kidney, colon, liver, prostate and small intestine, HGD uses iron as a cofactor to catalyse the oxygen-dependent conversion of homogentisate to 4-maleylacetoacetate, a reaction that is the fourth step in the creation of L-phenylalanine from fumarate and acetoacetic acid. Defects in the gene encoding HGD are the cause of alkaptonuria (AKU), an autosomal recessive disorder that is characterised by urine that turns dark on standing and alkalinisation, black ochronotic pigmentation of cartilage and collagenous tissues and spine arthritis.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4893R-A488)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4893R-A488

Beschreibung: NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4892R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4892R-A555

Beschreibung: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4892R-A750)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4892R-A750

Beschreibung: Apolipoprotein-E (apoE) is a protein component of plasma lipoproteins that mediates the binding, internalization and catabolism of lipoprotein particles. It can serve as a ligand for several lipoprotein receptors, including the LDL (ApoB/E) receptor and the hepatic apoE (chylomicron remnant) receptor. apoE is produced in most organs and occurs in all plasma lipoprotein fractions, constituting 10-20% of VLDL (very low density lipoprotein) and 1-2% of HDL (high density lipoprotein). Three major isoforms of apoE have been described in human (E2, E3 and E4) which differ by only one or two amino acids. oestrogen receptor has been shown to upregulate apoE gene expression via the ERa-mediated pathway, indicating a potential role for apoE in atherosclerosis. This is consistent with studies in mice in which plasma apoE levels were raised, thereby protecting the mice from diet-induced atherosclerosis. apoE has also been shown to be a potent inhibitor of proliferation and thus may play a role in angiogenesis, tumor cell growth and metastasis.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12080R-HRP)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-12080R-HRP

Beschreibung: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R Alpha 1-6, GABAA R Beta 1-3, GABAA R Gamma 1-3, GABAA R Delta, GABAA R Epsilon, GABAA R Zeta 1 and GABAA R Zeta 2. The GABAB family is composed of GABAB R1 Alpha and GABAB R1 Beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7904R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-7904R-CY3

Beschreibung: The A Kinase Anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP6 is a member of the AKAP family. It is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3695R-A350)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-3695R-A350

Beschreibung: NTF97 is involved in nuclear protein import, either by associating itself with an adapter protein (for example, importin-alpha subunit which binds to nuclear localization signals (NLS) in cargo substrates), or by acting autonomously as a nuclear transport receptor (serves as NLS receptor, docking of the importin/substrate complex to the nuclear pore complex).

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11641R-A680)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11641R-A680

Beschreibung: BPTF is a 2907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyse ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11641R-CY7)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-11641R-CY7

Beschreibung: BPTF is a 2,907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyze ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8278R-CY3)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-8278R-CY3

Beschreibung: Belonging to the major facilitator superfamily, DIRC2 (disrupted in renal carcinoma protein 2) is a 478 amino acid multi-pass membrane protein that is primarily expressed in kidney proximal tubular cells. The genes encoding DIRC2 and DIRC3 are located at a translocation breakpoint which occurs frequently in individuals affected by familial renal cell carcinoma. Fusion transcripts that result from these translocations may affect normal protein function. This evidence suggests that, due to its chromosomal location, deregulation of the DIRC2 gene may cause haploinsufficiency and therefore result in the onset of tumor growth. There are two isoforms of DIRC2 which are produced as a result of alternative splicing events.

UOM: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4176R-A555)

Lieferant: Bioss

Hersteller Artikel Nummer : BS-4176R-A555

Beschreibung: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

UOM: 1 * 100 µl

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