Anti-SREBP-1/2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Lieferant: Bioss
BS-1402R-FITC
BOSSBS-1402R-FITCEA 1210 CHF
BOSSBS-1402R-FITC
Anti-SREBP-1/2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Antikörper
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the solubleMore Product Information
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