HMDS (1,1,1,3,3,3-Hexamethyldisilazan) Silylierungsreagenz, zur GC-Derivatisierung

Lieferant: MACHEREY-NAGEL
Gefahr

Synonyms: Bis(trimethylsilyl)amin

MANA701240.510EA 60.9 CHF
MANA701240.510 MANA701240.650
HMDS (1,1,1,3,3,3-Hexamethyldisilazan) Silylierungsreagenz, zur GC-Derivatisierung
HMDS (1,1,1,3,3,3-Hexamethyldisilazan)

HMDS is weak TMS donor. If used as sole reagent, it is slow and not very effective. After addition of catalytic quantities (e.g., 1 %) of TMCS or as a mixture with TMCS it is a fast and quantitative reagent for trimethylsilylation of organic compounds.


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • HMDS reagent mixed with TMCS catalyst shows fast and quantitative reaction


Aprotic solvents like acetonitrile, pyridine, dimethylformamide, carbon disulfide and dimethylacetamide are recommended for use with HMDS.

Formel: (CH₃)₃SiNHSi(CH₃)₃
MW: 161,39 g/mol
Siedepunkt: 126 °C (760 mm Hg)
Dichte: 0,7742 g/cm³ (d20°/4°)
MDL Number: MFCD00008259
CAS-Nummer: 999-97-3
UN: 3316
ADR: 9,II
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